University of California San Francisco

MacKenzie Lab - Homepage

Tippi MacKenzie 354x210

Tippi MacKenzie, MD

Professor of Surgery
Benioff UCSF Professor of Children’s Health
Director, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF
Co-Director, Center for Maternal-Fetal Precision Medicine
John G. Bowes Distinguished Professor of Stem Cell and Tissue Biology

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MacKenzie Lab

Mission:

Understanding the fundamental mechanisms of maternal-fetal biology in order to develop innovative fetal therapies for genetic diseases and pregnancy complications.

To create a collaborative interdisciplinary research environment to train the next generation of scientists/physicians.

Our Vision:

To translate discoveries in biology and technology into prenatal therapies that will transform medical care for expectant families.

Our Values:

The MacKenzie Lab is a diverse group of scientists from various backgrounds and from all over the world. As such, we approach each other with cultural humility, and we believe...

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Our Research
The blood-brain (BBB) and blood-spinal cord barriers (BSCB) are vital in regulating the molecules, proteins, drugs, and cells ...
We are currently performing two clinical trials of prenatal therapies that were tested in the MacKenzie lab. These ...
Successful, safe gene therapy technologies often need equally safe and efficacious delivery vector to reach their intended target ...
Sacrococcygeal Teratomas (SCTs), which grow on the tailbone, are the most common tumor in fetuses and neonates. Although ...
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Featured News

Featured Publications

  1. In utero hematopoietic stem cell transplantation for Fanconi anemia.
    2024 | PubMed
  2. The Conundrum of Mechanics Versus Genetics in Congenital Hydrocephalus and Its Implications for Fetal Therapy Approaches: A Scoping Review.
    2024 | PubMed
  3. Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells.
    2024 | PubMed
  4. Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus.
    2024 | PubMed
  5. Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman syndrome phenotype in mice.
    2024 | PubMed